Know your media speed. AJA System test, or something similar, can help you know how capable your drives are, since your projects need to read and write, plus your Apache server runs from your boot volume.
Ram Disks are worth trying. While Ram Disk contents are lost when you reboot, they can be useful when you need the fastest possible drive speed. If you have sufficient ram, you can locate entire virtual machines onto ram disks.
If you use FlameTwo, you may eventually need to adminster multiple machines. Apple Remote Desktop is something you should check out. It's great for copying the same file to lots of machines (real or virtual) at the same time, and watching them all at once.
Parallels is often suggested for SC users. This is a great option for authoring. For serving, Virtual Box may be the best option. Definitely worth a try.
External Thunderbolt booting. For older macs with Thunderbolt ports, booting externally usually provides a far faster SSD opportunity than anything built-in. As an added bonus, it's quick and easy to fix computer issues by simply swapping CPUs and re-booting.
It's time to be more specific on SSD's. Yes they are "faster" than hard drives, but with so many SSD options, including Thunderbolt and M.2, you should always look at real MB/s rates.
The newest OS may not be the best for a FlameTwo setup. TigerServer VM's can run with a small RAM footprint, and benefit from today's fast core speeds. Worth a try when you're evaluating performance.
Which SuperCard version? The changes from 4.7.3 to 4.8 were significant. But without major revision, some projects could actually run slower with 4.8. FlameTwo standalones can be built in multiple SC versions, so you can see what works best for each project.
Before High Sierra, you could use a RAID for your boot volume, which may make some older hardware perform better. FlameTwo in some cases performs better with Sierra than High Sierra. Striped SSD's are hard to beat for speed.
As a testing and development platform, Mojave may suit your situation fine. I have found some inconsistency with how Mojave deals with the Apache to AAEB transfer, sometimes popping dialogs asking for approval. This would be inconvenient on a production system, so use caution.
Apple has designed our lovely Macs to be quiet. For servers (like FlameTwo) we actually just want them to be cool. Macs Fan Control (crystalidea.com) can help you set your fan the way your load requires.